GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs10935120 | 1 | rs4974484 | chr3:134219019 | ANAPC13 | chr3:134196547-134204865:- | 0.51 | 8.25 | 2.62E-15 | Height |
| BLCA | cis | rs10935120 | 1 | rs4974484 | chr3:134219019 | CEP63 | chr3:134204575-134293852:+ | 0.26 | 4.55 | 7.27E-6 | Height |
| BLCA | cis | rs10935120 | 1 | rs4974493 | chr3:134219993 | ANAPC13 | chr3:134196547-134204865:- | 0.51 | 8.18 | 4.34E-15 | Height |
| BLCA | cis | rs10935120 | 1 | rs4974493 | chr3:134219993 | CEP63 | chr3:134204575-134293852:+ | 0.26 | 4.46 | 1.07E-5 | Height |
| BLCA | cis | rs7655841 | 1 | rs4975193 | chr4:129980630 | C4orf33 | chr4:130014829-130033842:+ | -0.33 | -5.43 | 1.02E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs4975194 | chr4:129982377 | C4orf33 | chr4:130014829-130033842:+ | -0.33 | -5.43 | 1.02E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs477692 | 1 | rs503660 | chr10:131418999 | MGMT | chr10:131265454-131565783:+ | 0.23 | 5.05 | 6.77E-7 | Response to temozolomide |
| BLCA | cis | rs477692 | 1 | rs506274 | chr10:131409392 | MGMT | chr10:131265454-131565783:+ | 0.21 | 4.5 | 9.09E-6 | Response to temozolomide |
| BLCA | cis | rs477692 | 1 | rs508303 | chr10:131424996 | MGMT | chr10:131265454-131565783:+ | -0.24 | -5.29 | 2.05E-7 | Response to temozolomide |
| BLCA | cis | rs7112513 | 1 | rs510988 | chr11:116813804 | PCSK7 | chr11:117075789-117102811:- | -0.4 | -5 | 8.65E-7 | Protein quantitative trait loci |
| BLCA | cis | rs7112513 | 1 | rs511676 | chr11:116824884 | PCSK7 | chr11:117075789-117102811:- | -0.41 | -5.05 | 7.01E-7 | Protein quantitative trait loci |
| BLCA | cis | rs477692 | 1 | rs513736 | chr10:131406489 | MGMT | chr10:131265454-131565783:+ | 0.21 | 4.45 | 1.1E-5 | Response to temozolomide |
| BLCA | cis | rs477692 | 1 | rs516704 | chr10:131419879 | MGMT | chr10:131265454-131565783:+ | 0.21 | 4.61 | 5.51E-6 | Response to temozolomide |
| BLCA | cis | rs477692 | 1 | rs522891 | chr10:131430916 | MGMT | chr10:131265454-131565783:+ | -0.23 | -4.95 | 1.12E-6 | Response to temozolomide |
| BLCA | cis | rs477692 | 1 | rs530466 | chr10:131427717 | MGMT | chr10:131265454-131565783:+ | 0.25 | 5.62 | 3.67E-8 | Response to temozolomide |